It competitively inhibits complex I by mimicking it to accept the electrons from NADH. NADH is oxidized, but the electrons do not travel down the ETC through those other components. This means there will be limited electron transfer eventually to the ATP synthase, so Rotenone blocks ATP synthesis.
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It competitively inhibits complex I by mimicking it to accept the electrons from NADH. NADH is oxidized, but the electrons do not travel down the ETC through those other components. This means there will be limited electron transfer eventually to the ATP synthase, so Rotenone blocks ATP synthesis.
Mechanism here: https://en.wikipedia.org/wiki/Rotenone#Mechanism_o...