I dont know how to answer these questions. Can somone Help me out? Thanks. ?
What would be the effect of the following mutations on the production of the protein for which a gene codes?
A) A mutation in the promoter of a gene, so that RNA polymerase cannot bind to it.
B) A mutation in an intron of a gene.
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Answers & Comments
A)
If RNA polymerase can't bind to the gene then transcription will not take place. As a result translation will not occur and therefore protein will not formed.
DNA ----(Transcription)----> mRNA ------(Translation)----> Protein
B)
Mutations in introns will usually have no effect on the cell because the intron sequence is discarded before the mRNA is tranlsated. However, if the mutation causes the intron to be incorrectly spliced out of the mRNA, then this can have a dramatic effect on the gene expression because the sequences in the intron will be translated into protein and this will alter the protein produced in a dramatic fashion.