A question about SNP’s and diseases?
Hi, i wanted to ask a question about SNP’s and could they cause a disease.
Ok so, if a person with a disease that has been caused by a SNP or SNP’s and nobody else has ever had anything like this disease ever in the family could it be a result of the SNP’s that the persons cells while dividing have created? Resulting obviously in errors in bases.
Since the person has created the cells themselves then the SNP’s cannot be passed on to their children since the SNP’s where not present at birth?
This is called sporadic?
Are the paragraphs above correct?
Thanks for the help.
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Well, let me tell you that mutations are of two kinds, sporadic or de novo and inherited ones. What you are talking of is clearly the case of a sporadic mutation. Single Nucleotide Polymorphisms (SNPs) are created by mutations in the general population, but they are not termed as mutations if less than 1% of the population carries them, they are simply called SNPs. But more importantly, the mutation has to happen in the germ cells, for being inherited to the offspring. So that way, mutations can be either somatic or germ line. What u describe is a somatic mutation ( which you describe as an SNP) & so cann't be inherited.
It is just like various kind of cancers which are an outcome of sporadic mutations in different somatic tissues & thus are never propagated to the next generation.