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路透香港電---中國科學家發現了一種似乎可保護中國人免於多種癌症侵襲的基因變體。
專家在最新一期的《自然遺傳學》(Nature Genetics)雜誌表示，他們對近一萬名中國人的DNA進行逾六年半的研究後發現，這種基因變體在未患癌症人群中較為常見。
中國醫學科學院的林東昕在寫給路透的電子郵件中說：「我們發現了CASP8基因的一種變體，它似乎與中國人罹患肺癌、食道癌、胃癌、結腸癌、子宮頸癌和乳癌的較低風險有關。」
CASP8基因控制細胞的死亡，是科學界已知的事實。細胞凋亡非常重要，因為它能防止細胞不受控制地分裂和蔓延--此過程可能導致癌變。
北京癌症研究院的科學家在1997年1月到2003年7月間，對5,000名肺癌、食道癌、結腸癌、子宮頸癌、胃癌及乳癌患者，及4,972名非癌症患者的DNA進行研究。
他們在25%的非癌症患者體內發現這種基因變體，而20%的癌症患者體內有這種基因變體。
這個發現或許有助識別高危險群。「我們發現的這種基因變體，或可成為識別高危險群的基因標記，這是人類預防及早期發現癌症的重要一步，」林東昕說。
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Reuter Hong Kong---The Chinese scientists had discovered one kind as if may protect the Chinese the gene anomalous form which makes a sneak attack avoid many kinds of cancers.
The expert "Natural Genetics" (Nature Genetics) the magazine indicated in newest one issue that they conducts the exceed six years half research after near 10,000 Chinese's DNA discovered that this kind of gene anomalous form in has not developed cancer in the crowd to be more common.
East Chinese Academy of Medical Sciences's forest dawn in wrote said for in Reuter's email: “we had discovered the CASP8 gene's one kind of anomalous form, it as if suffers from the lung cancer, carcinoma esophagi, the stomach cancer, the colon cancer, the carcinoma of cervix and the breast cancer low risk with the Chinese related.”
The CASP8 gene control cell's death's, is the scientific circles known fact. The cell perishes weakly is important, because it can prevent the cell not to control the fission and the spread--This process causes the cancer possibly.
Beijing Cancer Research institute's scientists in January, 1997 from to July, 2003, to 5,000 lung cancer, carcinoma esophagi, the colon cancer, the carcinoma of cervix, the stomach cancer and the breast cancer patient, and 4,972 non-cancer patient's DNA conducted the research.
They discover this kind of gene anomalous form in 25% non-cancer patient in vivo, but 20% cancer patient in vivo has this kind of gene anomalous form.
Perhaps this discovery is helpful to distinguish the high dangerous group. “we discovered this kind of gene anomalous form, or may become distinguishes the high dangerous group the gene mark, this is the human prevention and early discovery cancer's important one step,” Lin Dongxin said.
Reuter Hong Kong---The Chinese scientists had discovered one kind as if may protect the Chinese the gene anomalous form which makes a sneak attack avoid many kinds of cancers.
The expert "Natural Genetics" (Nature Genetics) the magazine indicated in newest one issue that they conducts the exceed six years half research after near 10,000 Chinese's DNA discovered that this kind of gene anomalous form in has not developed cancer in the crowd to be more common.
East Chinese Academy of Medical Sciences's forest dawn in wrote said for in Reuter's email: “we had discovered the CASP8 gene's one kind of anomalous form, it as if suffers from the lung cancer, carcinoma esophagi, the stomach cancer, the colon cancer, the carcinoma of cervix and the breast cancer low risk with the Chinese related.”
The CASP8 gene control cell's death's, is the scientific circles known fact. The cell perishes weakly is important, because it can prevent the cell not to control the fission and the spread--This process causes the cancer possibly.
Beijing Cancer Research institute's scientists in January, 1997 from to July, 2003, to 5,000 lung cancer, carcinoma esophagi, the colon cancer, the carcinoma of cervix, the stomach cancer and the breast cancer patient, and 4,972 non-cancer patient's DNA conducted the research.
They discover this kind of gene anomalous form in 25% non-cancer patient in vivo, but 20% cancer patient in vivo has this kind of gene anomalous form.
Perhaps this discovery is helpful to distinguish the high dangerous group. “we discovered this kind of gene anomalous form, or may become distinguishes the high dangerous group the gene mark, this is the human prevention and early discovery cancer's important one step,” Lin Dongxin said.
2007-04-24 17:43:09 補充：
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